KMID : 0043320180410010030
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Archives of Pharmacal Research 2018 Volume.41 No. 1 p.30 ~ p.34
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Saroclazines A?C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84
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Li Feng
Guo Wenqiang Wu Li Zhu Tianjiao Gu Qianqun Li Dehai Che Qian
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Abstract
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Three new diketopiperazine derivatives (DKPs), saroclazines A?C (1?3) along with three known DKPs (4?6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A?B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1?3) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 ¥ìM.
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KEYWORD
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Fungi, Mangrove, Sarocladium kiliense, Cytotoxic activity
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